By lowering LDL "bad" cholesterol levels, milk thistle may lower the chance of developing heart disease. Sign Up to Receive Our Free Coroanvirus Newsletter. Interactions. Milk thistle has traditionally been used in pregnancy. No significant differences in the prevention of adverse drug reactions or treatment duration and outcome were observed.Zhang 2016, In a murine model, silybin protected against cisplatin-induced acute kidney injury through improving mitochondrial function via regulation of sirtuin 3 expression.Li 2017, In a pilot, randomized, double-blind, placebo-controlled clinical trial, hospitalized patients receiving cisplatin were administered placebo or oral silymarin 420 mg/day in 3 divided doses starting 1 to 2 days prior to cisplatin initiation and continuing through the end of 3 cycles of 21-day chemotherapy. Placebo or silymarin 420 mg/day (given in 3 divided doses) was administered orally as adjunctive therapy to a relatively stable iron chelation regimen for 12 weeks, with a 2-week washout between treatments. You should talk with your health care provider for complete information about the risks and benefits of using this product. In humans that are genetically prone to iron overload, milk thistle seed was shown to decreased iron absorption. This is only a brief summary of general information about this product. Additionally, varicocelized rats receiving silymarin had higher testosterone levels and a larger percentage of sperm with nuclear maturity compared with varicocelized rats not receiving treatment.Moshtaghion 2013, Milk thistle is considered safe in dosages of 420 mg/day orally in divided doses for up to 41 months.Milić 2013, Tamayo 2007 One source suggests daily doses of 12 to 15 g of dry fruits for dyspepsia and disorders of the biliary system, while an extract containing 200 to 400 mg/day of silymarin is considered effective in various liver disorders.van Wyk 2004, A dose of 140 mg of silymarin 3 times daily has been suggested for hepatic cirrhosis.Stolf 2017, S. marianum leaf extract 600 mg/day (200 mg capsules 3 times daily) given for 8 weeks was as effective as fluoxetine in adults with obsessive-compulsive disorder in a small study.Sayyah 2010, A phase 1 clinical study in prostate cancer patients determined a phase 2 dosage recommendation of silibinin (as Siliphos) 13 g/day orally in 3 divided doses.Flaig 2007, Ramasamy 2008, A preparation consisting of 150 mL of boiling water poured over 3.5 g of crushed milk thistle seed, steeped for 10 to 15 minutes, and given 3 to 4 times daily 30 minutes before meals has been suggested for digestive disorders.Blumenthal 2003 Consumption of silymarin in the form of tea may not be effective, as silymarin is poorly soluble in water.Awang 2009. Both silibinin and silymarin exerted activity against Candida albicans, Candida tropicalis, and Candida krusei.de Oliveira 2015 Additionally, silibinin demonstrated a membrane-damaging effect as well as antibiofilm activity on C. albicans.Yun 2017 Dehydroisosilybin A, a component of milk thistle, demonstrated synergistic effects with amphotericin B against Leishmania.Olías-Molero 2018 Another study found silybin may be an efflux pump inhibitor; the compound eliminated the plasmid from methicillin-resistant S. aureus (MRSA) 41577, restoring the bacteria's sensitivity to antibiotics. Milk thistle helps pets and humans alike by reducing the impact of their allergies, making life easier and all around more enjoyable. Milk thistle may have been combined with other plants or extracts in a specific preparation to treat these conditions. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. Milk thistle is also known as Mary thistle or holy thistle. The ancient Greek and Romans used milk thistle for snake bites.Mastron 2015 The 17th century English herbalist Nicholas Culpepper described milk thistle as beneficial in treating jaundice and in removing liver and spleen obstructions. It lowers pro-inflammatory cytokines which trigger immune responses. Steps to Take. Milk thistle is considered safe in dosages of 420 mg/day orally in divided doses for up to 41 months. The fruits make up the thistle portion along with its silvery pappus, which readily falls away and is not used for the extract preparation.Mastron 2015, Neha 2016, NIH 2018, USDA 2018, WHO 2004. Select one or more newsletters to continue. Gastroparesis: What to Eat and What to Avoid, Newly Diagnosed With Crohn's? WebMD does not provide medical advice, diagnosis or treatment. Use of silymarin was associated with less fibrosis as measured by the Ishak fibrosis score, but this association was not noted for clinical outcome measures.Freedman 2011 The American Association for Study of Liver Disease (AASLD) practice guidelines for primary biliary cirrhosis (2009) and primary biliary cholangitis (2018) state that the addition of silymarin to ursodeoxycholic acid provided no additional benefit.Lindor 2009, Lindor 2019, A meta-analysis evaluated English and Chinese randomized placebo-controlled trials from 1966 to December 2011 to determine the safety and efficacy of silymarin as monotherapy and combination therapy for treatment of chronic hepatitis B.Wei 2013 Data from 12 trials (N=1,096) suggest silymarin is equivalent to antiviral or hepatoprotective drugs with regard to effects on serum transaminases, viral load, and hepatic fibrosis markers. Growing Milk Thistle From Seeds The milk thistle's seeds should be sown outside about 1/2 inch deep in either March or April for summer flowering. Milk thistle can also produce estrogenic effects, so those who suffer from endometriosis or uterine fibroids should avoid milk thistle because of the possible contraindication. Significant changes were also found in some, but not all, lipid parameters, with a negative correlation observed between insulin sensitivity and triglycerides (P=0.038) and a positive correlation noted between changes in insulin resistance and triglycerides (P=0.034). This is due in part to the While milk thistle has been traditionally used in pregnant and breastfeeding women, its safety is unknown. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts. According to the studies, people who often develop acne formation have experienced a reduction of formation by 53% when they consume it regularly for We comply with the HONcode standard for trustworthy health information -, https://nccih.nih.gov/health/milkthistle/ataglance.htm, https://clinicaltrials.gov/ct2/results?cond=&term=milk+thistle&cntry=&state=&city=&dist=. Although the majority of studies were of poor quality, the positive synergistic effect is an important finding that can help inform future clinical studies.Wei 2013, In patients with hepatitis C, beneficial effects have not been noted with use of silymarin. The flowers are reddish-purple and ridged with sharp spines. The Long and Short of Milk Thistle Dosage Milk thistle has been extensively researched and has repeatedly been found to protect the liver organ in humans  . This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. Natural Medicines Comprehensive Database: "Milk Thistle Monograph. Very large doses may cause loose stools because of excessive bile production. Silybin A and B, diastereoisomers of silibinin in a 1:1 ratio, are considered the most biologically active components. People sometimes eat the stem and leaves of milk thistle in salads. Silymarin is composed of 65% to 80% of a complex of flavonolignans: silybin A, silybin B, isosilybin A, isosilybin B, silychristin, isosilychristin, silydianin, and the flavonoid taxifoline. The plant was first grown in Europe and the de-spined leaves were used in salads and eaten as a vegetable; the stalks and root parts were also consumed. These liver problems include cirrhosis, jaundice, hepatitis, and gallbladder disorders. People with diabetes often have high cholesterol. Milk thistle has traditionally been used in pregnancy. Milk thistle can also be taken with cholesterol-lowering medications, like statins. If you take any medicines regularly, talk to your doctor before you start using milk thistle. Add some to your horse’s daily ration for better liver health! Milk Thistle is the best herbal product to help out in such acne conditions. Extensive studies around the world have found that silymarin is safe and effective in treating a variety of liver diseases and other conditions, from kidney disease to mushroom or lead poisoning. Additionally, the number of patients diagnosed with drug-induced liver injury at 8 weeks was not different, nor was the percentage of patients with transient abnormal liver function tests. No significant differences were observed between groups with regard to incidence of adverse effects or attrition rate.Sayyah 2010, Silybin and silymarin have been studied in the treatment of aging skin and rosacea, as well as in skin cancer prevention.Berardesca 2008, Chambers 2017, Singh 2005, Singh 2009 S. marianum may be beneficial in slowing skin aging due to its ability to inhibit radicals. In a 2016 meta-analysis of 5 clinical trials in patients with type 2 diabetes (N=270), routine supplementation with silymarin reduced glucose levels (–26.86 mg/dL; 95% CI, –35.42 to –18.3) as well as hemoglobin A1c (–1.07%; 95% CI, –1.73% to –0.4%); however, no improvement in lipids was observed with silymarin.Voroneanu 2016 Because milk thistle has demonstrated glucose-lowering effects, blood glucose should be carefully monitored when using milk thistle–containing products in patients with type 2 diabetes. At the end of the first to sixth week, median World Health Organization and National Cancer Institute Common Terminology Criteria scores were significantly reduced in the patients treated with silymarin (P<0.05). Era of Hope Meeting for the Department of Defense Breast Cancer Research Program, Atlanta, June 8-11, 2000. Milk thistle seed, as well as silymarin extract, can cause mild to moderate laxative effects. The more commonly used milk thistle seed extracts are not known to have estrogenic effects.Kidd 2005, Oral consumption of milk thistle (standardized to 70% to 80% silymarin) at 420 mg/day is considered safe for up to 41 months based on clinical trial data.Schandalik 1992 Acute oral toxicity of silymarin in rats, dogs, and monkeys has been estimated at dosages greater than 5 g/kg. Best Tips for Growing Milk Thistle You can buy organic milk thistle seeds online, but if you want them fresh, you may have to grow your own. The milk thistle seeds benefits are many for sure and the Jarrow’s formulation does its best to ensure that the user gets these benefits. It may have protective effects on the liver, preventing damage. Milk thistle can also change how your body metabolizes certain drugs, and while the drug interaction may not be harmful, milk thistle can reduce the efficacy of your medication. In a single-arm, non-randomized trial (n=44), 420 mg/day of silymarin given for 3 months improved joint tenderness, pain, swelling, erythrocyte sedimentation rate, C-reactive protein, and disease severity scores.Shavandi 2017, Milk thistle is believed to exert its hepatoprotective effects through the promotion of hepatocyte growth and inhibition of oxidation and inflammation in the liver.Ward 2013 Milk thistle may also increase protein synthesis in liver cells, a positive effect in degenerative liver diseases.Awang 2009 Some reports suggest that oral silybin as a phytosome complex is better for the treatment of liver conditions.Polachi 2016, In a study of alcohol-induced inflammation of guinea pig hepatocytes, silymarin 25 mg per 100 g of body weight given for 30 days was associated with a reduction in liver function markers (ie, AST, ALT, gamma-glutamyltransferase [GGT]) compared with controls (alcohol abstention group). Though traditional medicines often have a long history of being suspected to have positive effects, it is best to talk to your doctor before taking any herbal supplements, especially if you are already being treated for a known health condition. And the National Institute of Health also notes milk thistle as a treatment for liver disorders like hepatitis and cirrhosis, as well as gallbladder problems. The benefits of milk thistle are well-proven for both horses and humans. Milk thistle benefits the body with virtually no side effects from regular use and is relatively gentle in comparison to other liver herbs or supplements. It is native to Mediterranean countries. Milk thistle helps reduce and cure problems such as fatty liver, pancreatitis, dog liver cancer, hepatitis, and heartworms among other issues that can plague the health of your pet dog. 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