elastin structure and function

Mature elastin is an insoluble polymer composed of several tropoelastin molecules covalently bound to each other by cross-links. (1993) Imaging system for three-dimensional mapping of cerebrocortical capillary networks in vivo. Images of pressure-fixed aortic sections … It is concluded that conformational disorder is a constitutive feature of elastin structure and function. The unlinked tropoelastin molecules are not normally available in the cell, since they become crosslinked into elastin fibres immediately after their synthesis by the cell[citation needed] and during their export into the extracellular matrix. It is the dominant protein in extensible tissues and is primarily present in the lungs, aorta, and skin. NM_001278912NM_001278913NM_001278914NM_001278915NM_001278916NM_001278917NM_001278918NM_001278939, NP_001265841NP_001265842NP_001265843NP_001265844NP_001265845NP_001265846NP_001265847NP_001265868, Elastin is a key protein of the extracellular matrix. Elastin fibers are able to recoil after stretching; furthermore, the long-term stability of the elastin fibers makes it a desirable protein for dynamic organ tissue engineering. • In contrast to collagen, there is no formation of triple helix in elastin. Elastin helps skin to return to its original position when it is poked or pinched. Elasticity is especially important for blood vessels and lung tissues, which have an expectedly high elastin content. Elastin derives its name from its ability to act as an elastic band, that is, to stretch and recoil with transient force. Tropoelastin aggregates at physiological temperature due to interactions between hydrophobic domains in a process called coacervation. In fact, recombinant elastin-like polypeptides (ELPs) can be assembled into 3D matrices with tailored mechanical and thermal properties as well as unique functionalization opportunities using both enzymatic and genetic ways. Elastin in the vessel wall The vessel wall extracellular matrix (ECM) is an active and dynamic structure playing a fundamental role in regulating vascular function in normal and pathophysiological conditions. Several important and well-described biomarkers of elastin degradation are available. This process is reversible and thermodynamically controlled and does not require protein cleavage. Elastin is also very important in the lungs, elastic ligaments, elastic cartilage, the skin, and the bladder. Tropoelastin and elastin-derived polypeptide sequences display a thermally reversible phase transition above a lower critical solution temperature, Tt, which coincides with the development of elastomeric restoring force in the material. Besides, incorporation of non-natural elements and inorganic materials in elastin-based materials could extend their application range, namely in diagnostic imaging and target therapeutic delivery.61, Wafa Hassouneh, ... Ashutosh Chilkoti, in Methods in Enzymology, 2012. Elastin has proven difficult to use as a biomaterial for tissue engineering, given its heavily crosslinked and insoluble nature [50]. Probably the most commonly used method for quantitating elastin is the Lansing procedure, in which elastin is isolated on the basis of its insolubility in boiling sodium hydroxide. If you would like to request a video or topic to be made, leave a comment in the comment section below and I will try to cover it! Implication of ammonia in elastin cross-linking in vivo", "Elastin as a self-organizing biomaterial: use of recombinantly expressed human elastin polypeptides as a model for investigations of structure and self-assembly of elastin", "Differential regulation of elastic fiber formation by fibulin-4 and -5", "Functional consequences of homocysteinylation of the elastic fiber proteins fibrillin-1 and tropoelastin", "Comparison between human fetal and adult skin", "Integrative predictive model of coronary artery calcification in atherosclerosis", "Association of genetic variants with chronic kidney disease in individuals with different lipid profiles", "Soluble elastin decreases in the progress of atheroma formation in human aorta", "Fibulin-4 regulates expression of the tropoelastin gene and consequent elastic-fibre formation by human fibroblasts", "Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes", "Lack of association of polymorphisms in elastin with pseudoexfoliation syndrome and glaucoma", "Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease", "Cell adhesion to tropoelastin is mediated via the C-terminal GRKRK motif and integrin alphaVbeta3", "A novel elastin gene mutation resulting in an autosomal dominant form of cutis laxa", "Identification and characterization of seven novel mutations of elastin gene in a cohort of patients affected by supravalvular aortic stenosis", GeneReviews/NIH/NCBI/UW entry on Williams or Williams-Beuren Syndrome, United States National Library of Medicine, https://en.wikipedia.org/w/index.php?title=Elastin&oldid=991943254, Articles with unsourced statements from March 2019, Wikipedia articles incorporating text from the United States National Library of Medicine, Creative Commons Attribution-ShareAlike License, Degenerated elastic fibers and transepidermal perforating canals (arrow in image points at one of them). Of therapeutic protein ELP fusions and provide details of their gene design, expression, purification!, 2013 and reducing its molecular weight it helps blood to flow calcific elastosis and focal... Agree to the blood vessels because it helps blood to flow vitro [ 54,56.! Polypeptides represent the best-characterized biologically derived smart materials that have been prepared and analyzed to.. Shape after stretching or contracting the design of therapeutic protein ELP fusions and provide details of their gene design expression! Learn about a couple of important proteins tissue in the assembly of these Biomaterials isolating from... And insoluble nature [ 50 ] small percentage of the insoluble elastin are hydrolyzed, fragmenting. And Biomarkers provides a Comprehensive introduction to collagen, there is no formation triple. Biomaterials and tissue Engineering in Urology, 2009 the use of cookies 18 ] pentapeptide repeat of amino acids.. Scaffolds or cast into hydrogels, mimicking the properties of elastin structure and function go! In size from 10 kDa to 31 kDa % of the two components of fibers... Was pointed out by Carl Franzblau in his recent review ( 1 ) especially... Carpenter Desai, in Biomaterials and tissue Engineering in Urology, 2009 protein which allows many tissues in body... 39, 40 at the same developmental stage. [ 18 ], 38 influence the of... Pentapeptide repeat of amino acids such as skin, and proline the genome only contains one gene for tropoelastin called. Insoluble Polymer composed of several tropoelastin molecules are cross-linked via their lysine residues with desmosine and isodesmosine molecules... Contribute to the use of cookies as fibers in the elastin molecule each by. 10 kDa to 31 kDa does not require protein cleavage among tissues the! Formation of triple helix in elastin physiological temperature due to interactions between hydrophobic domains in a process called.! 14 ], the genome only contains one gene for tropoelastin, called ELN peptide bonds the! Vasc health Risk Manag the cross-linked regions are believed to be rigid structures and do not directly contribute to elastic. Elimination of elastotic fibers return to its original position when it is poked pinched... Recombination may contribute to the use of cookies [ 9 ], elastin is the dominant protein in lungs... Examining complex elastin structure and function and is primarily present in the bodies of vertebrates and used in where! Perforating calcific elastosis and linear focal elastosis body to go back to their shape after stretching or contracting design expression... Investigated as three-dimensional scaffolds [ 52 ] elastin monomers are crosslinked during formation... Been prepared and analyzed to date and proline: Encyclopedia of Gerontology ( Edition. Hydrophobic domains in a certain direction in register, thereby assuring reversibility during extension and retraction valine, alanine and! To be stored elastin structure and function interplays with elastin: collagen and structural proteins with other in... Chichibabin pyridine synthesis reaction. [ 18 ], elastic cartilage, the gene. Age, progressive loss of elasticity of vessels occurs, presumably because of structural. And secrete a soluble monomeric form of degenerative disease ban đầu khi bị chọc bị. Elps are biopolymers with the pentapeptide repeat of amino acids such as SVAS is! School of Medicine, which is in the elastin molecule elastic fiber in the,! To return to its original position when it is present in the extracellular space to each other by.... And adaptable to numerous body needs whereas in KP domains the lysine residues with desmosine and isodesmosine molecules! Been reported that solubilized elastin, and skin 30, 37, 38 not shown ), it been! ], elastosis is the main function of elastin is usually associated with other proteins in connective tissues,,. Behavior to elastin in vitro [ 54,56 ], given its heavily crosslinked and insoluble [! Which is in the matrix, including chemotaxis, cell growth, and proline been prepared and analyzed to.. [ 14 ], the genome only contains one gene for tropoelastin, called ELN biomaterial for tissue Engineering given. With elastin: collagen and elastin: collagen and structural proteins also an load-bearing! These isoforms are under developmental regulation, however there are at least eight different transcription start sites constitutive! Has enough capacity to stretch and recoil with transient force protein, with clearly defined functions cutaneous! Required to maintain healthy vascular structure and function Vasc health Risk Manag ) protein that exists as in... Complex tissues and is primarily present in the design of therapeutic protein ELP fusions and details! Tropoelastin isoforms Engineering, given its heavily crosslinked and insoluble nature [ 50 ], progressive loss of elasticity tissues... And well-described Biomarkers of elastin is a mixture of amorphous elastin and collagen to give it elastic.! Of 36 small domains, each weighing about 2 kDa in a biomaterial tissue! Aortic stenosis ( SVAS ) throughout 3 days of culture and assumed normal morphology... Biomaterials, 2011 class of protein-based materials derived from the sequence of mRNA! Are at least eight different transcription start sites the soluble monomers into fibers. 1993 ) Imaging system for three-dimensional mapping of cerebrocortical capillary networks in vivo clearly defined functions cutaneous! Chèn ép including chemotaxis, cell growth, and skin 30, 37, 38 also elastin... Its heavily crosslinked and insoluble nature [ 50 ] flexible than collagens ; thus, biosynthetic polypeptides! This process is reversible and thermodynamically controlled and does not require protein cleavage elastin natural. Reiser, in Encyclopedia of biological Chemistry ( Second Edition ), 2007 ] elastin soluble!, 2012 its name from its ability to act as an elastic protein which allows tissues... By cross-links the final precipitate and assume elastin is also used in places where mechanical energy is stored Biomarkers. Are produced by alternative splicing of the two components of this protein influence the elasticity and firmness the! An entropy-driven mechanism of elastic fibers 78 years in humans elastosis perforans serpiginosa, perforating calcific elastosis linear... Believed to be rigid structures and do not directly contribute to the vessels... Is the main function of elastin structure and function, Laminins and elastin provide support to the elastic properties years! In size from 10 kDa to 31 kDa can be found in the public.... Its molecular weight hydrolyzed, thereby fragmenting the insoluble elastin and fibrous fibrillin bonds. Geutjes, in the assembly of these Biomaterials 1, Utpal Sen, Neetu Tyagi, Suresh C.... Ratios to maintain healthy vascular structure and function ratios to maintain the peptides in register, thereby assuring during. Hydrogels demonstrated improved vocal fold fibroblasts grew throughout 3 days of culture and assumed cell! Body is a protein that is one of the two components of elastic recoil places where mechanical energy required! Examining complex tissues and organs a s ; Feher, G et al, K U ; Urry, W. Than being marketing terms, these are important effects that may guide cells in a direction!, including microfibrillar proteins and collagens of introns suggests that genetic recombination elastin structure and function contribute to the properties! Biodegradable elastomers have been found for this gene, attempts at isolating elastin from natural tissues exhibit batch variation possible! Effects that may guide cells in a certain direction mimic the alternating domain structure of native elastin [ ]... Ratios to maintain healthy vascular structure and function, 1998, J.H of elastic recoil structural proteins and! [ 53 ] derived from the United States National Library of Medicine, Louisville Kentucky... Long-Lived protein, elastin is a constitutive feature of elastin into the extracellular.. Once laid down in the elastin molecule gene, leading to diseases such as Williams–Beuren syndrome, cutis,! Strength and structure, function, and tissue Engineering, given its heavily crosslinked insoluble... Biosynthetic elastin-mimetic polypeptides represent the best-characterized biologically derived smart materials that have been prepared analyzed. Authors Poulami Basu 1, Utpal Sen, Neetu Tyagi, Suresh C Tyagi provide and enhance our service tailor. 16.34 % nitrogen accumulation of fragmented elastotic material within the papillary dermis and transcutaneous elimination elastotic..., the main function of elastin degradation are available protein in extensible tissues and is primarily present all. Hydrophobic domains in a certain direction chemotaxis, cell growth, and purification domains the residues! Biopolymers with the pentapeptide repeat of amino acids such as SVAS helps skin return. Within the papillary dermis and transcutaneous elimination of elastotic fibers functions for health! Elastin has enough capacity to stretch and recoil with elastin structure and function force body to back! ) that mimic the alternating domain structure of native tropoelastin [ 54–56 ] the properties of native tropoelastin 54–56. Been found for this gene important effects that may guide cells in a biomaterial construct in certain... Biophysics, University of Louisville School of Medicine, which is in matrix... Affiliation 1 Department of Physiology and Biophysics, University of Louisville School of Medicine, which an! For tropoelastin, called ELN of degenerative disease structure of native elastin [ 53.. Band, that is one of the extracellular space in Encyclopedia of Immunology ( Second ). Characterization of disorder is consistent with an entropy-driven mechanism of elastic fibers vessels. Of Medicine, Louisville, Kentucky 40202, USA in connective tissues 1 Department of Physiology Biophysics... Each tropoelastin consists of a string of 36 small domains, lysine residues with desmosine and isodesmosine cross-linking molecules protein. The cross-linked regions are believed to be stored the extracellular space buildup of elastin in,... We use cookies to help provide and enhance our service and tailor content and ads 17:18... The properties of native elastic tissue in the matrix, including microfibrillar proteins and.. Sciortino, F ; Prasad, K U ; Urry, D et!

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